Pharmacoepidemiology

Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing Parkinson Disease

**Importance:** Parkinson disease (PD) is a common neurodegenerative disease. A treatment that prevents or delays development of PD is a critical unmet need. Terazosin and closely related drugs were recently discovered to enhance glycolysis and …

The Cardiovascular Effects of Treatment with Hydroxychloroquine and Azithromycin

Hydroxychloroquine combined with azithromycin has been investigated for activity against coronavirus disease 2019 (COVID-19), but concerns about adverse cardiovascular (CV) effects have been raised. This study evaluated claims data to determine if …

Longitudinal assessment of post-ureteroscopic laser lithotripsy pain and opioid consumption using text messaging: Tailoring pain management to the patient

**Introduction:** We identified patterns of postoperative pain and opioid consumption and associated factors following ureteroscopy for kidney stones by acquiring real-time data through automated text messages. **Methods:** Adult patients undergoing …

Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases

Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are common features of PD. Previous studies revealed that terazosin (TZ) …

Web search query volume as a measure of pharmaceutical utilization and changes in prescribing patterns

**BACKGROUND:** Monitoring prescription drug utilization is important for both drug safety and drug marketing purposes. However, access to utilization data is often expensive, limited and not timely. **OBJECTIVES:** To demonstrate and validate the …