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Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing Parkinson Disease

**Importance:** Parkinson disease (PD) is a common neurodegenerative disease. A treatment that prevents or delays development of PD is a critical unmet need. Terazosin and closely related drugs were recently discovered to enhance glycolysis and …

Warmer Weather and the Risk of Urinary Tract Infections in Women

**PURPOSE:** The incidence of urinary tract infections is seasonal, peaking in summer months. One possible mechanism for the observed seasonality of urinary tract infections is warmer weather. **MATERIALS AND METHODS:** We identified all urinary …

Preserved Ratio Impaired Spirometry in a Spirometry Database

**BACKGROUND:** Spirometry results can yield a diagnosis of normal air flow, air flow obstruction, or preserved ratio impaired spirometry (PRISm), defined as a reduced FEV1 or FVC in the setting of preserved FEV1/FVC. Previous studies have estimated …

A pharmacist intervention for monitoring and treating hypertension using bidirectional texting: PharmText BP

**BACKGROUND:** New approaches are needed to better monitor blood pressure (BP) between physician visits, especially for patients in rural areas or for those who lack transportation. We have developed a custom-built bi-directional texting platform …

Continuous in-home PM2.5 concentrations of smokers with and without a history of respiratory exacerbations in Iowa, during and after an air purifier intervention

**BACKGROUND:** Americans spend most of their time indoors. Indoor particulate matter (PM) 2.5 µm and smaller (PM2.5) concentrations often exceed ambient concentrations. Therefore, we tested whether the use of an air purifying device (electrostatic …

The Cardiovascular Effects of Treatment with Hydroxychloroquine and Azithromycin

Hydroxychloroquine combined with azithromycin has been investigated for activity against coronavirus disease 2019 (COVID-19), but concerns about adverse cardiovascular (CV) effects have been raised. This study evaluated claims data to determine if …

Seasonal Antimicrobial Activity of the Airway: Post-Hoc Analysis of a Randomized Placebo-Controlled Double-Blind Trial

**BACKGROUND:** It is widely unknown why respiratory infections follow a seasonal pattern. Variations in ultraviolet B (UVB) light during seasons affects cutaneous synthesis of vitamin D3. Serum vitamin D concentration influences the expression of …

Longitudinal assessment of post-ureteroscopic laser lithotripsy pain and opioid consumption using text messaging: Tailoring pain management to the patient

**Introduction:** We identified patterns of postoperative pain and opioid consumption and associated factors following ureteroscopy for kidney stones by acquiring real-time data through automated text messages. **Methods:** Adult patients undergoing …

Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases

Parkinson's disease (PD) is a common neurodegenerative disease that lacks therapies to prevent progressive neurodegeneration. Impaired energy metabolism and reduced ATP levels are common features of PD. Previous studies revealed that terazosin (TZ) …

Uninterrupted Classroom Sitting is Associated with Increased Discomfort and Sleepiness Among College Students

Acute bouts of uninterrupted sitting has been associated with discomfort and fatigue in adult populations. However, little is known regarding the impact of uninterrupted sitting on such outcomes among college students. Understanding these relations …